CellSearch® Tumor Phenotyping Reagent HER-2/neu
For Research Use Only. Not for use in diagnostic procedures. The performance characteristics and safety and effectiveness have not been established and are not cleared or approved by the FDA.
The CellSearch® Tumor Phenotyping Reagent HER-2/neu is a fluorescein conjugated monoclonal antibody that is to be used in conjunction with the CellSearch® Epithelial Cell Kit to phenotype circulating tumor cells (CTCs) for the presence of HER-2/neu. The CellSearch® Epithelial Cell Kit captures and stains CTCs of epithelial origin. These CTCs may have detached from a tumor and have entered the peripheral blood circulation.
Analysis of HER-2/neu expression on circulating tumor cells may be of research interest because the HER-2/neu receptor, which is over expressed in 15%-30% of invasive breast carcinomas,1 is associated with poor outcomes.
CellSearch® Tumor Phenotyping Reagent EGFr
For Research Use Only. Not for use in diagnostic procedures. The performance characteristics and safety and effectiveness have not been established and are not cleared or approved by the FDA.
The CellSearch® Tumor Phenotyping Reagent EGFr (epidermal growth factor receptor) is a fluorescein conjugated monoclonal antibody that is to be used in conjunction with the CellSearch® Epithelial Cell Kit to phenotype circulating tumor cells (CTCs) for the presence of EGFr. The CellSearch® Epithelial Cell Kit captures and stains CTCs of epithelial origin. These CTCs may have detached from a tumor and have entered the peripheral blood circulation.
EGFr is a 170 kd transmembrane glycoprotein with an extracellular domain that serves as the binding site for epidermal growth factor and transforming growth factor alpha (TGF-alpha).2,3 EGFr is predominantly expressed in squamous cell carcinomas.
References:
1. Brown RE. HER-2/neu positive breast carcinoma: molecular concomitants by proteomic analysis and their therapeutic implications. Ann Clin Lab Sci.2002;32(1):12-21.
2. Marquandt H, et al. Human transforming growth factors. J Biol Chem. 1982;257:5220-5225.
3. Carpenter G, et al. Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor. Proc Natl Acad Sci. 1983;80:5627-5630.
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