Q: What is the CellSearch^® CTC Test?

A: The CellSearch^® CTC Test is a simple blood test that captures, identifies, and counts circulating tumor cells (CTCs) in a tube of blood. Clinical studies have shown that detection of these cells can predict disease progression and survival in men and women with metastatic colorectal cancer.

Q: What are circulating tumor cells (CTCs)?

A: CTCs are cancer cells that have detached from a solid tumor and entered into the bloodstream. These cells play an important role in the metastatic process, and their presence can provide valuable insight into disease progression.

Q: How does this information help my doctor?

A: Measuring the number of CTCs in your blood before and during your course of treatment can help your doctor in monitoring your progress. Clinical studies have shown that 3 or more CTCs in a blood sample are an indication that the disease is progressing. If your test shows there are less than 3 CTCs in your sample, this means the disease is not currently progressing. If it shows an increase to 3 or more, your doctor may choose to adjust your treatment accordingly.

Q: What types of tests do doctors currently use?

A: Currently, doctors use lab tests, physical exams, and radiographic imaging studies, such as CT scans, to determine progression of the disease. Imaging measures changes (both increases and decreases) in the size of the tumor to determine if the treatment is working. Depending on the type of treatment, imaging is performed at different intervals of time, but it typically starts about 12 weeks after therapy has begun.

Q: How is the CTC test different?

A: Unlike traditional diagnostic tests, such as imaging, the CTC test measures the number of CTCs in your blood to help determine whether or not the disease is progressing. The test can be performed at the start of therapy and at any time during the course of your treatment. This critical information can help your doctor make important treatment decisions earlier, and as needed.

Q: If I have metastatic colorectal cancer, should I ask for the test?

A: Every patient is different, so you should discuss the test with your doctor to determine whether it is right for you.

Q: How often should I get the CTC test?

A: Typically, a blood sample is taken for the CTC test before a new line of therapy begins to establish a baseline, and then again at any time during the course of your treatment. You should discuss with your doctor the frequency of testing that is right for you.

Q: Where do I get the CellSearch^® CTC Test?

A: Since it is a simple blood test, any doctor can order the CTC test. The blood sample can be drawn right in the doctor’s office.

Q: What if my doctor doesn’t know about the CellSearch^® CTC Test?

A: Your doctor can learn more about the test by going to www.veridex.com, or by calling 1-877-VERIDEX and selecting option 6.

Q: Who is Veridex?

A: Veridex, the company that brings you the CellSearch^® CTC Test, is a Johnson & Johnson company dedicated to delivering innovative new cancer diagnostic tools that positively impact patients’ lives.